![]() ![]() One of the underlying causes of neurodegenerative diseases are neurofibrillary tangles (NFTs) of the tau protein, which cause the death of neurons, leading to the symptoms of AD,” explained the authors. It is a progressive brain disorder that slowly destroys memory and thinking ability. His published paper in Science The title is “TRIM11 protects against tauopathies and is down-regulated in Alzheimer’s disease.” Commenting on the research, senior author Xiaolu Yang, PhD, professor of cancer biology at Penn, said, “For the first time, we have identified the gene that oversees tau function, and developed treatments to stop and slow it.” is a promising goal to pursue.” Progression of Alzheimer’s disease and other related disorders.”ĪD is the most common cause of dementia among older adults, with an estimated six million Americans currently suffering from the disease. The team’s study identified TRIM11 as playing a key role in clearing protein tangles that cause tauopathies, including AD, and indicated that TRIM11 plays an important role in protecting against tauopathies, and that its downregulation may contribute to the development of such diseases. decline while improving cognitive and motor abilities. Their studies using human postmortem brain tissue, cell lines and animal models showed that the gene encoding tripartite motif protein 11 (TRIM11) – a protein associated with tau production – was expressed in the brains of mouse models with neurodegenerative diseases similar to AD. Newly reported research led by a team from the University of Pennsylvania’s Perelman School of Medicine points to a potential gene therapy approach for neurodegenerative disorders characterized by tangles of tau protein in the brain. ![]()
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